Recent Developments in Amide Synthesis: Direct Amidation of Carboxylic Acids and Transamidation Reactions
نویسندگان
چکیده
منابع مشابه
Borate esters as convenient reagents for direct amidation of carboxylic acids and transamidation of primary amides.
Simple borates serve as effective promoters for amide bond formation with a variety of carboxylic acids and amines. With trimethyl or tris(2,2,2-trifluoroethyl) borate, amides are obtained in good to excellent yield and high purity after a simple work-up procedure. Tris(2,2,2-trifluoroethyl) borate can also be used for the straightforward conversion of primary amides to secondary amides via tra...
متن کاملDirect amide formation from unactivated carboxylic acids and amines.
The direct coupling of unactivated carboxylic acids with amines can be performed in toluene 110 °C in the absence of catalyst. The use of simple zirconium catalysts at 5 mol% loading gave amide formation in as little as 4 h.
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چکیده ندارد.
Recent Developments in Amide Synthesis Using Nonactivated Starting Materials.
Amides are unquestionably one of the most important functional groups in organic chemistry because of their presence in numerous interesting molecules such as peptides, pharmaceutical agents, naturally occurring molecules, proteins and alkaloids, among others. This synopsis surveys the diverse recent approaches to amide synthesis from nonactivated carboxylic acids and derivatives as well as non...
متن کاملRelative Reactivities of Activated Carboxylic Acids in Amide- Forming Reactions Employed for the Synthesis of Tetraphenylporphyrin Libraries
Presented here is a method for rapidly testing the reactivity of carboxylic acids in amide-forming reactions. For this, a mixture of two acids, one a reference compound, and one acid whose reactivity is unknown, are coupled to an aminoacylated tetrakis(paminophenyl)porphyrin under typical peptide coupling conditions. The product distribution in the resulting library is analyzed via MALDI-TOF ma...
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ژورنال
عنوان ژورنال: European Journal of Organic Chemistry
سال: 2013
ISSN: 1434-193X
DOI: 10.1002/ejoc.201300573